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Galactose PEG Succinimidyl Carboxymethyl Ester

产品代号:

GALA-PEG-SCM

产品纯度:

≥ 95%

包装规格:

1g, 10g, 100g等(特殊包装需收取分装费用)

分子量:

35000 Da等

产品咨询:

科研客户小批量一键采购地址(小于5克)

  • 产品描述
  • 参考文献
  •   半乳糖羧甲基琥珀酰亚胺酯含有一个羧甲基琥珀酰亚胺酯活性基因和一个半乳糖类靶向基因,能与氨基高效反应的亲水性聚乙二醇衍生物。

      在室温条件下,PH=7-8的环境中,活性酯基因能快速地与赖氨酸中的氨基链接。单糖基团半乳糖大大提高了聚乙二醇化反应的选择性。

      必赢网址bwi437科技提供分装服务,需要收取分装费用,如果您需要分装为其他规格请与我们联系。

      必赢网址bwi437科技同时提供其他分子量的GALA-SCM直连衍生物产品,如你需要请与我司sales@jenkem.com联系。

      必赢网址bwi437科技提供大批量生产产品及GMP级别产品,如需报价请与我们联系。

     

  •   References:

      1. He, H., et al., Development of mannose functionalized dendrimeric nanoparticles for targeted delivery to macrophages: use of this platform to modulate atherosclerosis, Translational Research, 2018, 193, P. 13-30.

      2. He, H., et al., Bolstering cholesteryl ester hydrolysis in liver: A hepatocyte-targeting gene delivery strategy for potential alleviation of atherosclerosis, Biomaterials, 2017, 130:1-3.

      3. Weaver, E.A., et al., Effects of Shielding Adenoviral Vectors with Polyethylene Glycol on Vector-Specific and Vaccine-Mediated Immune Responses, Human Gene Therapy, 2008, 19:1369–1382.

      4、Luan, J., et al., GSDMD membrane pore is critical for IL-1β release and antagonizing IL-1β by hepatocyte-specific nanobiologics is a promising therapeutics for murine alcoholic steatohepatitis, Biomaterials, 2020, V. 227.

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